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salicylic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
analgesic anti-inflammatory	2416	69-72-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: choline salicylate choline subsalicylate salicylic acid 2-Carboxyphenol 2-Hydroxybenzenecarboxylic acid 2-Hydroxybenzoic acid imidazole salicylate sodium salicylate morpholine salicylate potassium salicylate	A compound obtained from the bark of the white willow and wintergreen leaves. It has bacteriostatic, fungicidal, and keratolytic actions. Molecular weight: 138.12 Formula: C7H6O3 CLOGP: 2.19 LIPINSKI: 0 HAC: 3 HDO: 2 TPSA: 57.53 ALOGS: -1.09 ROTB: 1

Molecule

Description

Molfile Inchi Smiles

Synonyms:

choline salicylate
choline subsalicylate
salicylic acid
2-Carboxyphenol
2-Hydroxybenzenecarboxylic acid
2-Hydroxybenzoic acid
imidazole salicylate
sodium salicylate
morpholine salicylate
potassium salicylate

A compound obtained from the bark of the white willow and wintergreen leaves. It has bacteriostatic, fungicidal, and keratolytic actions.

Molecular weight: 138.12
Formula: C7H6O3
CLOGP: 2.19
LIPINSKI: 0
HAC: 3
HDO: 2
TPSA: 57.53
ALOGS: -1.09
ROTB: 1

Drug dosage:

Dose	Unit	Route
3	g	O
3	g	O
7	g	O

ADMET properties:

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Property	Value	Reference
BA (Bioavailability)	99 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility)	2.51 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	15 %	Benet LZ, Broccatelli F, Oprea TI
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI

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Approvals:

Date	Agency	Company	Orphan
Jan. 1, 1898	YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	704.54	16.45	216	7936	24160	63456710
Completed suicide	311.52	16.45	207	7945	145466	63335404
Chronic sinusitis	209.46	16.45	74	8078	12769	63468101
Paraesthesia oral	183.72	16.45	75	8077	19181	63461689
Procedural pain	175.50	16.45	75	8077	21494	63459376
Toxicity to various agents	126.68	16.45	157	7995	247093	63233777
Erythema	122.69	16.45	131	8021	175620	63305250
Therapeutic product effect incomplete	118.28	16.45	110	8042	124946	63355924
Vaginal flatulence	111.28	16.45	33	8119	3260	63477610
Skin burning sensation	105.93	16.45	45	8107	12689	63468181

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	290.02	17.90	172	4399	97996	34854364
Toxicity to various agents	85.20	17.90	117	4454	200245	34752115
Anal inflammation	75.57	17.90	20	4551	1280	34951080
SARS-CoV-2 test negative	65.58	17.90	17	4554	1003	34951357
Choroiditis	62.63	17.90	17	4554	1198	34951162
Skin burning sensation	54.07	17.90	21	4550	4622	34947738
Accident	52.37	17.90	21	4550	5026	34947334
Endophthalmitis	52.25	17.90	19	4552	3489	34948871
Proctalgia	46.50	17.90	20	4551	5703	34946657
Intraocular pressure increased	34.71	17.90	16	4555	5367	34946993

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	559.43	14.90	380	11209	245387	79487412
Macular degeneration	202.09	14.90	72	11517	11224	79721575
Chronic sinusitis	192.08	14.90	72	11517	12954	79719845
Toxicity to various agents	190.65	14.90	268	11321	421272	79311527
Paraesthesia oral	160.60	14.90	72	11517	20399	79712400
Procedural pain	155.41	14.90	73	11516	23011	79709788
Skin burning sensation	144.89	14.90	59	11530	13213	79719586
Erythema	130.04	14.90	161	11428	223129	79509670
Vaginal flatulence	110.77	14.90	32	11557	2543	79730256
Therapeutic product effect incomplete	90.27	14.90	107	11482	141538	79591261

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	D01AE12	DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Other antifungals for topical use
ATC	N02BA03	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Salicylic acid and derivatives
ATC	N02BA04	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Salicylic acid and derivatives
ATC	N02BA08	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Salicylic acid and derivatives
ATC	N02BA12	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Salicylic acid and derivatives
ATC	N02BA16	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Salicylic acid and derivatives
ATC	S01BC08	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Antiinflammatory agents, non-steroids
CHEBI has role	CHEBI:35441	antiinfective agents
CHEBI has role	CHEBI:35718	antifungal agents
CHEBI has role	CHEBI:37848	plant hormones

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Tinea pedis	indication	6020002	DOID:12403
Pain	indication	22253000
Greasy skin	indication	42273000
Seborrheic dermatitis	indication	50563003	DOID:8741
Allergic rhinitis	indication	61582004
Verruca plantaris	indication	63440008	DOID:13775
Rheumatoid arthritis	indication	69896004	DOID:7148
Common cold	indication	82272006	DOID:10459
Tinea corporis	indication	84849002
Acne vulgaris	indication	88616000

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.81	acidic
pKa2	12.79	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN	Ki	5.15	CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN	Ki	5	CHEMBL
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN	Ki	4.95	CHEMBL
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN	Ki	4.10	CHEMBL
Carbonic anhydrase 12	Enzyme	O43570	CAH12_HUMAN	Ki	5.06	CHEMBL
Carbonic anhydrase 7	Enzyme	P43166	CAH7_HUMAN	Ki	4.09	CHEMBL
Carbonic anhydrase 6	Enzyme	P23280	CAH6_HUMAN	Ki	4.92	CHEMBL
Carbonic anhydrase 14	Enzyme	Q9ULX7	CAH14_HUMAN	Ki	4.30	CHEMBL
High mobility group protein B1	Nuclear other	P09429	HMGB1_HUMAN	Kd	6	CHEMBL
Nicotinate phosphoribosyltransferase	Enzyme	Q6XQN6	PNCB_HUMAN	Ki	9.80	CHEMBL

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External reference:

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ID	Source
SAL	PDB_CHEM_ID
001586	NDDF
001590	NDDF
001592	NDDF
001951	NDDF
005692	NDDF
006027	NDDF
147-90-0	SECONDARY_CAS_RN
1938	INN_ID
2016-36-6	SECONDARY_CAS_RN

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Almay Clear Complexion Blemish Armor	HUMAN OTC DRUG LABEL	1	0311-0722	LIQUID	2 mg	TOPICAL	OTC monograph final	10 sections
Almay Clear Complexion Blemish Healing Spot Concealer	HUMAN OTC DRUG LABEL	1	0311-0716	LIQUID	2 mg	TOPICAL	OTC monograph final	8 sections
Almay Clear Complexion Blemish Healing Spot Concealer	HUMAN OTC DRUG LABEL	1	0311-0718	LIQUID	0.01 g	TOPICAL	OTC monograph final	8 sections
ALMAY CLEAR COMPLEXION CONCEALER	HUMAN OTC DRUG LABEL	1	0311-0725	LIQUID	2 mg	TOPICAL	OTC monograph final	8 sections
Almay Clear Complexion Liquid Makeup	HUMAN OTC DRUG LABEL	1	0311-0720	LIQUID	2 mg	TOPICAL	OTC monograph final	8 sections
Almay Clear Complexion Liquid Makeup for Oily Skin	HUMAN OTC DRUG LABEL	1	0311-0715	LIQUID	0.50 mg	TOPICAL	OTC monograph final	7 sections
ALMAY CLEAR COMPLEXION MAKEUP	HUMAN OTC DRUG LABEL	1	0311-0724	EMULSION	1 mg	TOPICAL	OTC monograph final	7 sections
Almay Clear Complexion Pressed Powder	HUMAN OTC DRUG LABEL	1	0311-0721	POWDER	0.00 g	TOPICAL	OTC monograph final	8 sections
Cetaphil Acne Relief Body Wash	HUMAN OTC DRUG LABEL	1	0299-4121	GEL	20 mg	TOPICAL	OTC monograph final	10 sections
Cetaphil Acne Relief Body Wash	HUMAN OTC DRUG LABEL	1	0299-4121	GEL	20 mg	TOPICAL	OTC monograph final	10 sections

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